Coach Waimarama Taumaunu rested Maria Tuta'ia and Irene van Dyk to allow the Jodi Brown-Catherine Latu shooting combination time on court.
But England made the better start, racing out to a 13-9 lead after the first quarter.
Taumaunu kept her shooters out on court and wasn't disappointed.
The strategic move saw the Ferns claw their way back to lead 23-20 at half-time.
The Ferns maintained that dominance in the third quarter before extending their lead to 39-28.
Despite their lead, the Ferns wanted to finish strong, and added another 17 goals in the final quarter to win 49-32.
The Kiwis will take on England A tomorrow morning in the final match of their tour.